刘聪
刘聪，中科科学院上海有机化学研究所研究员。
简历
刘聪，男，中科科学院上海有机化学研究所研究员，课题组长
1998-2002 吉林大学 学士 Jilin University B.S.
2002-2008 北京大学 博士 Peking University Ph.D
2008-至今 美国加州大学洛杉矶分校＆霍华德休斯医学院 博士后 UCLA\u0026HHMI Postdoc
研究方向
1.与神经退行性疾病如阿尔兹海默症、帕金森病，亨廷顿氏病相关的蛋白质的错误折叠，异常积聚，和淀粉样化的分子机理研究。
2.基于重要生物靶点分子结构的小分子药物先导物的设计，筛选和优化。主要针对老年痴呆症和帕金森症相关的致病蛋白多聚体及淀粉样纤维的分子结构，进行小分子及多肽化合物的合理设计，筛选，及基于此先导物的机理和功能研究。
3.基于淀粉样多肽的具有新功能的新材料设计，开发和应用。
获奖及荣誉
2012 IUCr青年科学家国际旅行资助奖 国际晶体学会蛋白晶体学新方法会议
2012 ADDF 杰出青年科学家奖 第六届神经退行性疾病药物开发年会
2007 杰出墙报奖 第六届国际蛋白科学会议
代表论著
1.Jiang L*, Liu C*, Leibly D, Landau M, Zhao ML, Hughes M, Eisenberg D. Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta.eLife 2013;2:300857.
2. Gu L, Liu C, Guo Z. Structural insights into Aβ42 oligomers using site-directed spin
labeling. The Journal of Biological 化学, 2013, June 28, 288, 18673-1868.
3.Liu C*, Zhao ML*, Jiang L*., Cheng PN., Park JY, Sawaya M, Pensalfini A, Gou DW, Berk DW, Glabe C, Nowick, J and Eisenberg D. Out‐of‐register β‐sheets suggest a pathway to toxic amyloid aggregations. Proc. Nat. Acad. Sci. USA, 2012 Dec 18;109(51):20913-8
4.Cheng PN*, Liu C*, Zhao ML, Eisenberg D and Nowick J. Macrocyclic β‐sheet mimics that antagonize protein aggregation and reduce amyloid toxicity. Nature 化学,2012,doi:10.1038/nchem.1433.
5.Stroud JC*, Liu C*, Teng PK and Eisenberg D. Toxic fibrillar oligomers of amyloid‐βhave cross‐βstructure. Proc. Nat. Acad. Sci. USA., 2012, May 15;109(20):7717.
6.Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C and Eisenberg D. Atomic view of a toxic amyloid small oligomer. Science., 2012, Mar 9;335(6073):1228‐31.
7.Liu C*, Sawaya MR*, Cheng PN, Zheng J, Nowick JS and Eisenberg D. Characteristics of amyloid‐related oligomers revealed by crystal structures of macrocyclic β‐sheet mimics. J. Am. Chem. Soc., 2011, May 4;133(17):6736‐44.
8.Zheng J, Liu C, Sawaya MR, Vadla B, Khan S, Woods RJ, Eisenberg D, Goux WJ and Nowick JS. Macrocyclic β‐sheet peptides that inhibit the aggregation of a tau‐protein‐derived hexapeptide. J. Am. Chem. Soc., 2011, Mar 9;133(9):3144‐57(2011).
9.Liu, C, Sawaya, M.R. and Eisenberg, D. β2-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages. Nat. Struct. 摩尔 Biol., 2011, Jan;18(1):49‐55.
10.Liu C*, Li D*, Liang YH, Li LF and Su XD. Ring‐opening mechanism revealed by crystal structures of NagB and its ES intermediate complex. J. Mol. Biol., 2008, 379.
11. Li D*, Liu C*, Liang YH, Li LF and Su XD. Crystal structure of B. subtilis YjcG characterizing the YjcG‐like group of 2H phosphoesterase superfamily. Proteins: Structure, 函数, and 生物信息学, 2008, 72, 1071.
(* Authors contributed equally)